Nanopesticides for Sustainable Crop Protection: Formulation Strategies, Biological Efficacy, and Regulatory Challenges https://doi.org/10.21276/AATCCReview.2025 Veylan Oris https://orcid.org/register Selvara Nemi https://orcid.org/register Torven Alric https://orcid.org/register Mireya Solen https://orcid.org/register Kalen Varo https://orcid.org/register Norelia Daven https://orcid.org/register Elion Ravek https://orcid.org/register Sarven Liora https://orcid.org/register Tavira Elsen https://orcid.org/register Oren Valek https://orcid.org/register Nanopesticides have emerged as an innovative approach for sustainable crop protection by improving pesticide delivery, increasing biological efficacy, and minimizing environmental pollution. Compared with conventional pesticides, nanopesticides provide controlled release, enhanced stability, improved target specificity, and reduced chemical losses. Various formulation strategies, including nanoemulsions, polymeric nanoparticles, liposomes, and inorganic nanocarriers, have significantly enhanced the performance of pesticide active ingredients while reducing application frequency. Nanopesticides also support integrated pest management and precision agriculture by improving pest control efficiency and reducing adverse effects on non-target organisms. Despite these advantages, concerns regarding nanoparticle toxicity, environmental persistence, food safety, and regulatory approval remain major challenges for commercialization. This review summarizes recent developments in nanopesticide formulation strategies, biological efficacy, agricultural applications, regulatory issues, and future prospects for sustainable crop protection.

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Short Communication
Veylan Oris1 Selvara Nemi2 Torven Alric3 Mireya Solen4 Kalen Varo5 Norelia Daven6 Elion Ravek7 Sarven Liora8 Tavira Elsen9 Oren Valek10
1 Department of Nanoagricultural Sciences, Baltic Institute of Sustainable Crop Research, Tallinn, Estonia
2 Centre for Agricultural Nanotechnology, Andean Institute of Plant Protection, Quito, Ecuador
3 Department of Environmental Biotechnology, Nordic Centre for Agrochemical Innovation, Oslo, Norway
4 Institute of Crop Protection and Nanobiotechnology, Mediterranean Agricultural Research University, Athens, Greece
5 Department of Plant Health Sciences, Southern African Centre for Sustainable Agriculture, Pretoria, South Africa
6 School of Agricultural Biotechnology, Pacific Institute of Crop Science, Auckland, New Zealand
7 Department of Environmental Toxicology, Alpine Centre for Agricultural Innovation, Zurich, Switzerland
8 Institute of Nanomaterials and Agroecology, Carpathian University of Life Sciences, Bucharest, Romania
9 Department of Sustainable Crop Protection, Central Asian Institute of Agricultural Sciences, Tashkent, Uzbekistan
10 Centre for Agricultural Policy and Regulatory Sciences, Atlantic Institute of Food and Environmental Research, Lisbon, Portugal
https://doi.org/10.21276/AATCCReview.2025

Abstract

Nanopesticides have emerged as an innovative approach for sustainable crop protection by improving pesticide delivery, increasing biological efficacy, and minimizing environmental pollution. Compared with conventional pesticides, nanopesticides provide controlled release, enhanced stability, improved target specificity, and reduced chemical losses. Various formulation strategies, including nanoemulsions, polymeric nanoparticles, liposomes, and inorganic nanocarriers, have significantly enhanced the performance of pesticide active ingredients while reducing application frequency. Nanopesticides also support integrated pest management and precision agriculture by improving pest control efficiency and reducing adverse effects on non-target organisms. Despite these advantages, concerns regarding nanoparticle toxicity, environmental persistence, food safety, and regulatory approval remain major challenges for commercialization. This review summarizes recent developments in nanopesticide formulation strategies, biological efficacy, agricultural applications, regulatory issues, and future prospects for sustainable crop protection.

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